| Cat. No. |
Product Name |
Information |
| PC-36029 |
VS-II-173
Pim1/Pim3 inhibitor
|
VS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively, and a potent and selective inducer of AML cell death (IC50=5.5 uM, Molm-13 cell). |
| PC-35980 |
Pim inhibitor 28
Pim1/Pim2 inhibitor
|
Pim inhibitor 28 is a potent, selective inhibitor of Pim1/2 with IC50 of 0.05 nM for both, demonstrates on-target Pim activity in an in vivo pharmacodynamic assay with significant inhibition of BAD phosphorylation in KMS-12-BM multiple myeloma tumors. |
| PC-35943 |
pan-PIM inhibitor 17
pan-Pim inhibitor
|
pan-PIM inhibitor 17 is a potent, selective, orally available inhibitor of Pim kinase with IC50 of 0.8, 5.1 and 1.8 nM for Pim1, 2 and 3, respectively. |
| PC-35492 |
HS56
Pim/DAPK3 inhibitor
|
HS56 (Pim-DAPK3 inhibitor HS56) is a potent, dual Pim/DAPK3 inhibitor with Ki of 72 nM (Pim-3) and 315 nM (DAPK3), shows micromolar potency toward Pim-1 and Pim-2 (Ki=1.5 and 17 uM). |
| PC-35264 |
INCB053914
pan-Pim inhibitor
|
INCB053914 (INCB-053914) is a novel potent, and selective ATP-competitive, pan-PIM kinase inhibitor with IC50 of 0.24/30.0/0.12 nM for PIM1/2/3, respectively. |
| PC-63508 |
SEL24-B489 hydrochloride
PIM/FLT3-ITD inhibitor
|
SEL24-B489 (SEL24) hydrochloride is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively. |
| PC-63507 |
SEL24-B489
PIM/FLT3-ITD inhibitor
|
SEL24-B489 (SEL24, MEN1703) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively. |
| PC-43464 |
SGI-1776
Pim inhibitor
|
SGI-1776 is a potent, selective, orally active Pim kinase inhibitor with IC50 of 7, 363 and 69 nM for Pim1, Pim2 and Pim3, respectively. |
| PC-43239 |
M-110
Pim-3 inhibitor
|
M-110 is a potent, selective inhibitor of PIM kinase family with preference for PIM-3 with IC50 of 0.047, 2.5 and 2.5 uM for PIM3, PIM1 and PIM2, respectively. |
| PC-63142 |
JP-11646
Pim2 inhibitor
|
JP-11646 is a novel potent, selective, non-ATP competitive Pim2 inhibitor with IC50 of 0.5/1/24 nM for Pim2/3/1, respectively. |
| PC-63141 |
NMS-P645
Pim inhibitor
|
NMS-P645 is a potent, selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively. |
| PC-63140 |
GNE-955
pan-Pim inhibitor
|
GNE-955 (GNE955) is a potent, selective pan-Pim inhibitor with Ki of 0.018/0.11/0.008 nM for Pim1/2/3, respectively. |
