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Chemical Structure : pan-PIM inhibitor 17
Catalog No.: PC-35943Not For Human Use, Lab Use Only.
pan-PIM inhibitor 17 is a potent, selective, orally available inhibitor of Pim kinase with IC50 of 0.8, 5.1 and 1.8 nM for Pim1, 2 and 3, respectively.
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pan-PIM inhibitor 17 is a potent, selective, orally available inhibitor of Pim kinase with IC50 of 0.8, 5.1 and 1.8 nM for Pim1, 2 and 3, respectively.
pan-PIM inhibitor 17 disaplays broad selectivity in an internal panel of 192 kinases, only eight kinases were inhibited above 50% at 1 uM.
demonstrates cellular biomarker pS6 inhibition with EC50 of 27 nM, shows tumor growth inhibition in a KG1 tumor-bearing mouse model.
| M.Wt | 374.869 | |
| Formula | C19H23ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Barberis C, et al. Bioorg Med Chem Lett. 2018 Dec 10. pii: S0960-894X(18)30949-1.
2. Barberis C, et al. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4735-4740.
3. Guo Z, et al. Blood. 2014 Sep 11;124(11):1777-89.
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