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Chemical Structure : pan-PIM inhibitor 27
Catalog No.: PC-38740Not For Human Use, Lab Use Only.
pan-PIM inhibitor 27 (SARxxxx92) is a potent, selective, orally bioavailable pan-PIM kinase inhibitor with IC50 of 1, 6 nM for Pim1 and Pim2, respectively.
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pan-PIM inhibitor 27 (SARxxxx92) is a potent, selective, orally bioavailable pan-PIM kinase inhibitor with IC50 of 1, 6 nM for Pim1 and Pim2, respectively.
pan-PIM inhibitor 27 displays a very favorable selectivity profile against an internal panel of 192 kinases.
pan-PIM inhibitor 27 exhibits potent cellular activity with pS6EC50 of 71 nM, inhibits KG1 cell viability with IC50 of 61 nM.
pan-PIM inhibitor 27 (50-150 mg/kg, p.o. bid) inhibits tumor growth in KG1 mouse xenograph model.
| M.Wt | 324.784 | |
| Formula | C15H18ClFN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Claude Barberis, et al. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127625.
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