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Pim inhibitor 28

Chemical Structure : Pim inhibitor 28

CAS No.: 2314468-92-1

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Pim inhibitor 28

Catalog No.: PC-35980Not For Human Use, Lab Use Only.

Pim inhibitor 28 is a potent, selective inhibitor of Pim1/2 with IC50 of 0.05 nM for both, demonstrates on-target Pim activity in an in vivo pharmacodynamic assay with significant inhibition of BAD phosphorylation in KMS-12-BM multiple myeloma tumors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Pim inhibitor 28 is a potent, selective inhibitor of Pim1/2 with IC50 of 0.05 nM for both, demonstrates on-target Pim activity in an in vivo pharmacodynamic assay with significant inhibition of BAD phosphorylation in KMS-12-BM multiple myeloma tumors.

    Physicochemical Properties

    M.Wt 403.486
    Formula C23H25N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3H)-one

    References

    1. Wang HL, et al. J Med Chem. 2019 Jan 9. doi: 10.1021/acs.jmedchem.8b01733.

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