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DHPCC-9

Chemical Structure : DHPCC-9

CAS No.: 1192248-37-5

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DHPCC-9 (DHPCC9)

Catalog No.: PC-38739Not For Human Use, Lab Use Only.

DHPCC-9 is a selective Pim kinase inhibitor, inhibits Pim-1-dependent survival of cytokine-deprived myeloid cells (IC50=4-6 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DHPCC-9 is a selective Pim kinase inhibitor, inhibits Pim-1-dependent survival of cytokine-deprived myeloid cells (IC50=4-6 uM).
    DHPCC-9 represses intracellular phosphorylation of Bad by Pim kinases.
    DHPCC-9 decreases migration of prostate cancer cells without affecting Pim protein levels or cell viability, also reduces migration of squamocellular carcinoma cells.
    DHPCC-9 drastically decreases tumor volumes as well as the metastatic capacity in prostate cancer xenografts.

    Physicochemical Properties

    M.Wt 234.258
    Formula C15H10N2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde

    References

    1. Santio NM, et al. Mol Cancer. 2010 Oct 19;9:279.

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