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Chemical Structure : AZD2014
CAS No.: 1009298-59-2
Catalog No.: PC-21000Not For Human Use, Lab Use Only.
Vistusertib (AZD2014) is a potent and selective dual mTORC1 and mTORC2 inhibitor, inhibits both mTORC1 and mTORC2 in vitro (pS6 (S235/236), IC50=0.2 μM, pAKT (S473) IC50=0.08 μM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 1 g | Get quote |
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Vistusertib (AZD2014) is a potent and selective dual mTORC1 and mTORC2 inhibitor, inhibits both mTORC1 and mTORC2 in vitro (pS6 (S235/236), IC50=0.2 μM, pAKT (S473) IC50=0.08 μM).
Vistusertib (AZD2014) displays a high level of selectivity against other members of the PIKK family (IC50 against PI3K isoforms α, β, γ, δ = 3.8, >30, >30 and >29 μM, respectively) and was inactive against a general panel of over 200 kinases when tested at 10 μM.
Vistusertib (AZD2014) shows dose-dependent tumor growth inhibition in a mouse MCF7 xenograft model alongside modulation of mTORC1 and mTORC2 biomarkers.
| M.Wt | 462.55 | |
| Formula | C25H30N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide |
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1. Pike KG, et al. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1212-6.
2. Rastogi R, et al. J Biol Chem. 2013 Nov 22;288(47):33966-33977.
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