Catalog No.: PC-21000Not For Human Use, Lab Use Only.
Vistusertib (AZD2014) is a potent and selective dual mTORC1 and mTORC2 inhibitor, inhibits both mTORC1 and mTORC2 in vitro (pS6 (S235/236), IC50=0.2 μM, pAKT (S473) IC50=0.08 μM).
Vistusertib (AZD2014) is a potent and selective dual mTORC1 and mTORC2 inhibitor, inhibits both mTORC1 and mTORC2 in vitro (pS6 (S235/236), IC50=0.2 μM, pAKT (S473) IC50=0.08 μM). Vistusertib (AZD2014) displays a high level of selectivity against other members of the PIKK family (IC50 against PI3K isoforms α, β, γ, δ = 3.8, >30, >30 and >29 μM, respectively) and was inactive against a general panel of over 200 kinases when tested at 10 μM. Vistusertib (AZD2014) shows dose-dependent tumor growth inhibition in a mouse MCF7 xenograft model alongside modulation of mTORC1 and mTORC2 biomarkers.
