Cat. No. |
Product Name |
Information |
PC-38176 |
NV-5138
mTORC1 activator
|
NV-5138 (NV5138) is the first selective, orally bioavailable brain mTORC1 activator, binds to Sestrin2 (Kd=1.5 uM) and activates mTORC1 both in vitro and in vivo. |
PC-36112 |
MTI-31
|
MTI-31 (LXI-15029, mTOR inhibitor-31) is a novel potent, selective mTORC1/mTORC2 inhibitor with Kd of 0.2 nM (mTOR), displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G. |
PC-35517 |
ICSN3250
mTOR inhibitor
|
ICSN3250 (ICSN-3250) is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors. |
PC-43497 |
Sapanisertib
mTORC1/2 inhibitor
|
Sapanisertib (INK-128, MLN0128, TAK-228) is a potent, ATP-competitive, orally active dual mTORC1/2 inhibitor with Ki of 1.4 nM in cell-free assays, >200-fold selectivity over calss I PI3K isoforms. |
PC-43313 |
Torin2
mTOR inhibitor
|
Torin2 is a potent, selective, orally available inhibitor of mTOR, inhibits mTORC1-dependent T389 phosphorylation on S6K with IC50 of 0.25 nM, exhibits 800-fold selectivity over PI3K, and >100-fold over 440 other protein kinases. |
PC-43029 |
Zotarolimus
FKBP ligand
|
Zotarolimus (ABT-578, A 179578) is a semi-synthetic analogue of rapamycin, inhibits FKBP-12 binding with IC50 of 2.8 nM and shows less potent systemic immunosuppression than rapamycin. |
PC-42848 |
WYE-354
mTOR inhibitor
|
WYE-354 is a potent, selective and ATP-competitive inhibitor of mTOR with IC50 of 5 nM (recombinant mTOR ), displays >100-fold selectivity over PI3K isofoms. |
PC-60555 |
NV-128
|
NV-128 (LY-303511) is a novel isoflavone derivative that inhibits mTOR and promotes caspase-independent cell death. |
PC-60554 |
ME-344
|
ME-344 is a novel mitochondrial and mTOR inhibitor with potent anti-cancer activity, inhibits leukemia cell lines with IC50 of 70-260 nM. |
PC-60418 |
RapaLink-1
mTOR inhibitor
|
RapaLink-1 is a third-generation mTOR inhibitor that overcomes resistance to existing first- and second-generation inhibitors. |
PC-60132 |
Temsirolimus
mTOR inhibitor
|
Temsirolimus (CCI779, Torisel) is a rapamycin ester and mTOR inhibitor with biochemical IC50 of 1.74 uM. |
PC-45649 |
Seco Rapamycin sodium salt
|
Seco-rapamycin is the first in vivo open-ring metabolite of rapamycin that does not affect mTOR.. |