| Cat. No. |
Product Name |
Information |
| PC-45461 |
mTOR-IN-1
mTOR inhibitor
|
mTOR-IN-1 is a potent and selective mTOR inhibitor with Ki of 1.5 nM. |
| PC-42577 |
OSI-027
mTOR inhibitor
|
OSI-027 (ASP7486) is a potent and selective inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. |
| PC-42038 |
PQR-620
mTOR inhibitor
|
PQR-620 (PQR620) is a potent and selective, brain penetrant inhibitor of mTORC1/2, displays >1000-fold selectivity towards mTOR over PI3Kα in enzymatic binding assays. |
| PC-45102 |
CC-115 hydrochloride
DNA-PK/mTOR inhibitor
|
CC-115 hydrochloride is a potent, dual inhibitor of mTOR and DNA-PK with IC50 of 21 nM and 13 nM, respectively. |
| PC-42464 |
Rapamycin
mTOR inhibitor
|
Rapamycin (Sirolimus) is a macrolide compound that has potent immunosuppressive and antiproliferative properties by inhibiting mTOR (IC50=0.1 nM), induces autophagy. |
| PC-27312 |
DEPTOR-IN-3
DEPTOR inhibitor
|
DEPTOR-IN-3 (Compound 4g) is a small molecule inhibitor of DEPTOR-mTOR interaction, induces p70 phosphorylation, shows anti-myeloma cytotoxic properties. |
| PC-27311 |
DEPTOR-IN-2
DEPTOR inhibitor
|
DEPTOR-IN-2 (Compound 3g, Drug 3g) is a small molecule inhibitor of DEPTOR-mTOR interaction, prevents binding of recombinant DEPTOR to mTOR with IC50 of 1 uM, induces DEPTOR degradation, shows anti-myeloma cytotoxic properties. |
| PC-27310 |
NSC126405
DEPTOR inhibitor
|
NSC126405 is a small-molecule DEPTOR inhibitor that prevent DEPTOR binding to mTOR, acutely activates mTORC1 and selectively induces MM cell apoptosis and cell cycle arrest, binds to recombinant DEPTOR but not mTOR. |
| PC-27309 |
DEPTOR-IN-1
DEPTOR inhibitor
|
DEPTOR-IN-1 (Compound C3) is a small molecule putative DEPTOR inhibitor with MST KD of 9.3 uM, exhibits antimultiple myeloma activity with IC50 of 1.09 uM for RPMI 8226 cells. |
| PC-26526 |
eALM1137
mTOR inhibitor
|
eALM1137 is a highly potent, selective mTOR inhibitor with IC50 of 4.8 nM, weakly inhibits DNA-PK with IC50 of 77 nM (17-fold selectivity). |
| PC-24226 |
TMBIM6 inhibitor BIA
TMBIM6 inhibitor
|
TMBIM6 inhibitor BIA is a specific inhibitor of TMBIM6 (BAX inhibitor-1, BI-1), prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, also suppresses ER release of Ca2+ from TMBIM6, has broad anticancer activities. |
| PC-62011 |
CIDD 0067106
|
CIDD 0067106 is a novel natural product-based diaryloxazole that potent and selective antiproliferative activities against androgen receptor-positive breast cancer cells (MDA-MB-453 cell GI50=0.8 uM). |
