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Chemical Structure : Deforolimus
CAS No.: 572924-54-0
Catalog No.: PC-45902Not For Human Use, Lab Use Only.
Deforolimus (AP-23573, MK-8669, Ridaforolimus) potent, selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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Deforolimus (AP-23573, MK-8669, Ridaforolimus) potent, selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line.
Deforolimus displays significant antiproliferative activity a broad panel of cell lines with EC50 of 0.2-2.3 nM.
Deforolimus potently and selectively inhibits VEGF production in a dose-dependent manner.
Deforolimus exerts significant antitumor effects in mice bearing PC-3 (prostate), HCT-116 (colon), MCF7 (breast), PANC-1 (pancreas) or A549 (lung) xenografts.
| M.Wt | 990.2061 | |
| Formula | C53H84NO14P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 44 mg/mL |
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| Chemical Name/SMILES |
Rapamycin, 42-(dimethylphosphinate) (9CI) |
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1. Rivera VM, et al. Mol Cancer Ther. 2011 Jun;10(6):1059-71.
2. Legrier ME, et al. Cancer Res. 2007 Dec 1;67(23):11300-8.
3. Becker MA, et al. BMC Cancer. 2016 Oct 20;16(1):814.
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