AZD-8055 is a potent, selective, ATP-competitive and orally bioavailable mTOR inhibitor with IC50 of 0.8 nM.
AZD-8055 shows excellent selectivity (1,000-fold) against all class I PI3K isoforms and other PI3K-like kinases.
AZD-8055 inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1, and phosphorylation of the mTORC2 substrate AKT and downstream proteins, also fully inhibits rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1.
AZD-8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells, exhibits tumor growth inhibition in vivo.
