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Chemical Structure : AZD-8055
CAS No.: 1009298-09-2
Catalog No.: PC-42576Not For Human Use, Lab Use Only.
AZD-8055 is a potent, selective, ATP-competitive and orally bioavailable mTOR inhibitor with IC50 of 0.8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 100 mg | $358 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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AZD-8055 is a potent, selective, ATP-competitive and orally bioavailable mTOR inhibitor with IC50 of 0.8 nM.
AZD-8055 shows excellent selectivity (1,000-fold) against all class I PI3K isoforms and other PI3K-like kinases.
AZD-8055 inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1, and phosphorylation of the mTORC2 substrate AKT and downstream proteins, also fully inhibits rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1.
AZD-8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells, exhibits tumor growth inhibition in vivo.
| M.Wt | 465.5447 | |
| Formula | C25H31N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzenemethanol, 5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy- |
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1. Chresta CM, et al. Cancer Res. 2010 Jan 1;70(1):288-98.
2. Sini P, et al. Autophagy. 2010 May;6(4):553-4.
3. Jiang Q, et al. Cancer Res. 2011 Jun 15;71(12):4074-84.
4. Willems L, et al. Leukemia. 2012 Jun;26(6):1195-202.
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