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Chemical Structure : CZ-415
CAS No.: 1429639-50-8
Catalog No.: PC-42092Not For Human Use, Lab Use Only.
CZ-415 (CZ415) potent, highly selective, ATP-competitive and orally bioavailable mTOR inhibitor with pKd of 8.2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CZ-415 (CZ415) potent, highly selective, ATP-competitive and orally bioavailable mTOR inhibitor with pKd of 8.2.
CZ-415 displays >100-fold selectivity over PI3Ks.
CZ-415 inhibits downstream targets phosphorylation of pS6RP (S240/244) and pAkt (S473) in HEK293T cells with IC50 of 14.5 nM and 14.8 nM, inhibits IFNγ production in stimulated human whole blood with IC50 of 226 nM.
CZ-415 shows efficacy in a semitherapeutic collagen induced arthritis (CIA) mouse model.
| M.Wt | 459.5618 | |
| Formula | C22H29N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Urea, N-[4-[5,7-dihydro-7,7-dimethyl-4-[(3S)-3-methyl-4-morpholinyl]-6,6-dioxidothieno[3,4-d]pyrimidin-2-yl]phenyl]-N'-ethyl- |
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1. Cansfield AD, et al. ACS Med Chem Lett. 2016 Jun 10;7(8):768-73.
2. Zhang W, et al. Biochem Biophys Res Commun. 2017 Jun 3;487(3):494-499.
3. Yin G, et al. Oncotarget. 2017 May 30;8(47):82027-82036.
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