CZ-415 |CAS:1429639-50-8 Probechem Biochemicals

Chemical Structure : CZ-415

CAS No.: 1429639-50-8

CZ-415 (CZ415)

Catalog No.: PC-42092Not For Human Use, Lab Use Only.

CZ-415 (CZ415) potent, highly selective, ATP-competitive and orally bioavailable mTOR inhibitor with pKd of 8.2.

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$198	In stock
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Biological Activity

CZ-415 (CZ415) potent, highly selective, ATP-competitive and orally bioavailable mTOR inhibitor with pKd of 8.2.
CZ-415 displays >100-fold selectivity over PI3Ks.
CZ-415 inhibits downstream targets phosphorylation of pS6RP (S240/244) and pAkt (S473) in HEK293T cells with IC50 of 14.5 nM and 14.8 nM, inhibits IFNγ production in stimulated human whole blood with IC50 of 226 nM.
CZ-415 shows efficacy in a semitherapeutic collagen induced arthritis (CIA) mouse model.

Physicochemical Properties

M.Wt	459.5618
Formula	C22H29N5O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	Urea, N-[4-[5,7-dihydro-7,7-dimethyl-4-[(3S)-3-methyl-4-morpholinyl]-6,6-dioxidothieno[3,4-d]pyrimidin-2-yl]phenyl]-N'-ethyl-

References

1. Cansfield AD, et al. ACS Med Chem Lett. 2016 Jun 10;7(8):768-73.

2. Zhang W, et al. Biochem Biophys Res Commun. 2017 Jun 3;487(3):494-499.

3. Yin G, et al. Oncotarget. 2017 May 30;8(47):82027-82036.

CZ-415 (CZ415)

Biological Activity

Physicochemical Properties

References

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