Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-PI3K/Akt/mTOR Pathway-mTOR-CC-115 hydrochloride
CC-115 hydrochloride

Chemical Structure : CC-115 hydrochloride

CAS No.: 1300118-55-1

CC-115 hydrochloride (CC115 hydrochloride)

Catalog No.: PC-45102Not For Human Use, Lab Use Only.

CC-115 hydrochloride is a potent, dual inhibitor of mTOR and DNA-PK with IC50 of 21 nM and 13 nM, respectively.

Packing Price Stock Quantity
10 mg $98 In stock
25 mg $158 In stock
50 mg $258 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CC-115 hydrochloride is a potent, dual inhibitor of mTOR and DNA-PK with IC50 of 21 nM and 13 nM, respectively.
CC-115 hydrochloride blocks both mTORC1(pS6) and mTORC2(pAktS473) signaling in PC-3 cancer cells, in vitro and in vivo.
CC-115 hydrochloride exhibits dose-dependent efficacy in tumor xenograft models.

Physicochemical Properties

M.Wt 372.8122
Formula C16H17ClN8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

Pyrazino[2,3-b]pyrazin-2(1H)-one, 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-, hydrochloride (1:x)

References

1. Mortensen DS, et al. J Med Chem. 2015 Jul 23;58(14):5599-608.

2. Thijssen R, et al. Blood. 2016 Jul 28;128(4):574-83.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: