Catalog No.: PC-42463Not For Human Use, Lab Use Only.
Everolimus (RAD001) is a potent, highly specific, orally active mTOR inhibitor with IC50 of 5-6 nM for binding to FKBP-12 or FKBP-12 complexed to mTOR.
Everolimus (RAD001) is a potent, highly specific, orally active mTOR inhibitor with IC50 of 5-6 nM for binding to FKBP-12 or FKBP-12 complexed to mTOR.
Everolimus (RAD001) inhibits proliferation in vitro (IC50=1 nM-1 uM) in sensitive and insensitive tumor.
Everolimus (RAD001) dose-dependently inhibits tumor growth in vivo.
Physicochemical Properties
M.Wt
958.2244
Formula
C53H83NO14
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 54 mg/mL
Chemical Name/SMILES
Rapamycin, 42-O-(2-hydroxyethyl)-
References
1. Sedrani R, et al. Transplant Proc. 1998 Aug;30(5):2192-4.
2. Schuler W, et al. Transplantation. 1997 Jul 15;64(1):36-42.
3. Lane HA, et al. Clin Cancer Res. 2009 Mar 1;15(5):1612-22.
