| Cat. No. |
Product Name |
Information |
| PC-49619 |
XL388
mTOR inhibitor
|
XL388 (XL-388) is a potent, selective and orally bioavailable mTOR inhibitor with IC50 of 9.9 nM. |
| PC-49618 |
RMC-6272
mTORC1 inhibitor
|
RMC-6272 (RMC6272) is a potent, selective bi-steric inhibitor of mTORC1 with cellular IC50 of 0.44 nM for p4EBP1 inhibition, 27-fold selectivity over mTORC2. |
| PC-49617 |
RMC-5552
mTORC1 inhibitor
|
RMC-5552 (RMC5552) is a potent, selective bi-steric inhibitor of mTORC1 with cellular IC50 of 0.48 nM for p4EBP1 inhibition, 40-fold selectivity over mTORC2. |
| PC-49337 |
NV-5297
mTORC1 activator
|
NV-5297 (NV5297) is a novel small molecule mTORC1 pathway activator, modulates the Sestrin2-Gator2 interaction and activates the mTORC1 pathway in vitro and in vivo. |
| PC-38333 |
BC-LI-0186
LeuRS inhibitor
|
BC-LI-0186 is a potent, specific inhibitor of Leucyl-tRNA synthetase (LRS), inhibits the leucine-dependent mTORC1 pathway. |
| PC-38176 |
NV-5138
mTORC1 activator
|
NV-5138 (NV5138) is the first selective, orally bioavailable brain mTORC1 activator, binds to Sestrin2 (Kd=1.5 uM) and activates mTORC1 both in vitro and in vivo. |
| PC-36112 |
MTI-31
mTOR inhibitor
|
MTI-31 (LXI-15029, mTOR inhibitor-31) is a novel potent, selective mTORC1/mTORC2 inhibitor with Kd of 0.2 nM (mTOR), displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G. |
| PC-35518 |
ICSN3250 hydrochloride
mTOR inhibitor
|
ICSN3250 (ICSN-3250) hydrochloride is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors. |
| PC-35517 |
ICSN3250
mTOR inhibitor
|
ICSN3250 (ICSN-3250) is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors. |
| PC-63577 |
GPI-1046
FKBP12 ligand
|
GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12. |
| PC-43497 |
Sapanisertib
mTORC1/2 inhibitor
|
Sapanisertib (INK-128, MLN0128, TAK-228) is a potent, ATP-competitive, orally active dual mTORC1/2 inhibitor with Ki of 1.4 nM in cell-free assays, >200-fold selectivity over calss I PI3K isoforms. |
| PC-43313 |
Torin2
mTOR inhibitor
|
Torin2 is a potent, selective, orally available inhibitor of mTOR, inhibits mTORC1-dependent T389 phosphorylation on S6K with IC50 of 0.25 nM, exhibits 800-fold selectivity over PI3K, and >100-fold over 440 other protein kinases. |
