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Chemical Structure : RMC-5552
Catalog No.: PC-49617Not For Human Use, Lab Use Only.
RMC-5552 (RMC5552) is a potent, selective bi-steric inhibitor of mTORC1 with cellular IC50 of 0.48 nM for p4EBP1 inhibition, 40-fold selectivity over mTORC2.
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RMC-5552 (RMC5552) is a potent, selective bi-steric inhibitor of mTORC1 with cellular IC50 of 0.48 nM for p4EBP1 inhibition, 40-fold selectivity over mTORC2.
RMC-5552 displays >53-fold selectivity over other lipid kinases.
Treament of RMC-5552 resulted in a dose-dependent, prolonged, and profound inhibition of tumor p4EBP1 levels up to 48 h in Michigan Cancer Foundation-7 (MCF-7) breast cancer cell line, which bears an activating mutation in the p110α catalytic subunit of Phosphoinositide 3-kinase (PIK3CAE545K).
RMC-5552 (10 mg/kg, ip, qw) reduced tumor volume in MCF-7 CDX models.
| M.Wt | 1778.16 | |
| Formula | C93H136N10O24 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. G Leslie Burnett, et al. J Med Chem. 2023 Jan 12;66(1):149-169.
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