Chemical Structure : NUCC-201760
CAS No.:
NUCC-201760
(NUCC201760)
Catalog No.: PC-26250Not For Human Use, Lab Use Only.
NUCC-201760 is a specific small molecules inhibitor of mTORC2 complex component Stress-activated protein kinase-interacting protein 1 (SIN1) with IC50 of <1.5 uM in p-AKT S473 flow cytometry assay, selectively targets mTORC2 but not mTORC1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NUCC-201760 is a specific small molecules inhibitor of mTORC2 complex component Stress-activated protein kinase-interacting protein 1 (SIN1) with IC50 of <1.5 uM in p-AKT S473 flow cytometry assay, selectively targets mTORC2 but not mTORC1.
NUCC-201760 uniquely inhibits RAS activity and downstream MAPK signaling, disrupts the ability of RAS to switch from the GDP to GTP form which requires SIN1.
NUCC-201760 enhances responses to different FDA approved pharmacological agents in U937 cells.
NUCC-201760 alters post-translational modification, protein-protein interactions, and blocks mTORC2- and rapamycin sensitive (RS) mTORC1-mediated signaling.
NUCC-201760 potently inhibits the growth of colon cancer, melanoma, and leukemia cell lines.
Physicochemical Properties
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M.Wt
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523.98
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Formula
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C29H25ClF3N3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-1-(quinolin-8-ylmethyl)piperidine-4-carboxamide
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References
1. Beauchamp EM, et al. Mol Cancer Ther. 2025 Dec 22. doi: 10.1158/1535-7163.MCT-25-0298.
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