RMC-6272 | mTORC1 inhibitor | Probechem Biochemicals

Chemical Structure : RMC-6272

RMC-6272 (RMC6272)

Catalog No.: PC-49618Not For Human Use, Lab Use Only.

RMC-6272 (RMC6272) is a potent, selective bi-steric inhibitor of mTORC1 with cellular IC50 of 0.44 nM for p4EBP1 inhibition, 27-fold selectivity over mTORC2.

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Biological Activity

RMC-6272 (RMC6272) is a potent, selective bi-steric inhibitor of mTORC1 with cellular IC50 of 0.44 nM for p4EBP1 inhibition, 27-fold selectivity over mTORC2.
RMC-6272 displays >1000-fold selectivity over other lipid kinases.
RMC-6272 induces widespread apoptosis and deep tumor regressions in a xenograft model of KRASG12C mutant NSCLC bearing a loss of function mutation in STK11, a negative regulator of mTORC1.

Physicochemical Properties

M.Wt	1850.25
Formula	C95H141FN6O27S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R,4S)-2-Methoxy-4-((R)-2-((3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-5,9,27-trihydroxy-10,21-ddimethoxy-6,8,12,14,20,26-hexamethyl-1,11,28,29-tetraoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1]oxa[4]azacyclohentriacontin-3-yl)propyl)cyclohexyl (30-((4-(7-(6-Aminopyridin-3-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine-4-carbonyl)-2-fluoro-3-methylphenyl)sulfonyl)-27-oxo-3,6,9,12,15,18,21,24-octaoxa-28-az

References

1. G Leslie Burnett, et al. J Med Chem. 2023 Jan 12;66(1):149-169.

RMC-6272 (RMC6272)

Biological Activity

Physicochemical Properties

References

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