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Chemical Structure : RMC-6272
Catalog No.: PC-49618Not For Human Use, Lab Use Only.
RMC-6272 (RMC6272) is a potent, selective bi-steric inhibitor of mTORC1 with cellular IC50 of 0.44 nM for p4EBP1 inhibition, 27-fold selectivity over mTORC2.
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RMC-6272 (RMC6272) is a potent, selective bi-steric inhibitor of mTORC1 with cellular IC50 of 0.44 nM for p4EBP1 inhibition, 27-fold selectivity over mTORC2.
RMC-6272 displays >1000-fold selectivity over other lipid kinases.
RMC-6272 induces widespread apoptosis and deep tumor regressions in a xenograft model of KRASG12C mutant NSCLC bearing a loss of function mutation in STK11, a negative regulator of mTORC1.
| M.Wt | 1850.25 | |
| Formula | C95H141FN6O27S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. G Leslie Burnett, et al. J Med Chem. 2023 Jan 12;66(1):149-169.
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