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Chemical Structure : AZD3147
CAS No.: 1101810-02-9
Catalog No.: PC-60482Not For Human Use, Lab Use Only.
AZD3147 is a potent, selective dual mTORC1 and mTORC2 inhibitor with enzyme IC50 of 1.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $328 | In stock | |
| 25 mg | $528 | In stock | |
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| 100 mg | Get quote |
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AZD3147 is a potent, selective dual mTORC1 and mTORC2 inhibitor with enzyme IC50 of 1.5 nM.
AZD3147 weakly inhibits PI3K isoforms with IC50 of 1-10 uM, potently inhibits pAKT at Ser473 with pIC50 of 8.25.
AZD3147 has exellentphysicochemical and pharmacokinetic properties.
| M.Wt | 517.7 | |
| Formula | C24H31N5O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[4-[4-[1-(cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)-thiourea |
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1. Pike KG, et al. J Med Chem. 2015 Mar 12;58(5):2326-49.
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