AZD3147 |CAS:1101810-02-9 Probechem Biochemicals

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Chemical Structure : AZD3147

CAS No.: 1101810-02-9

AZD3147 (AZD-3147;AZD 3147)

Catalog No.: PC-60482Not For Human Use, Lab Use Only.

AZD3147 is a potent, selective dual mTORC1 and mTORC2 inhibitor with enzyme IC50 of 1.5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZD3147 is a potent, selective dual mTORC1 and mTORC2 inhibitor with enzyme IC50 of 1.5 nM.
AZD3147 weakly inhibits PI3K isoforms with IC50 of 1-10 uM, potently inhibits pAKT at Ser473 with pIC50 of 8.25.
AZD3147 has exellentphysicochemical and pharmacokinetic properties.

Physicochemical Properties

M.Wt	517.7
Formula	C24H31N5O4S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-[4-[1-(cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)-thiourea

References

1. Pike KG, et al. J Med Chem. 2015 Mar 12;58(5):2326-49.

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AZD3147 (AZD-3147;AZD 3147)

Biological Activity

Physicochemical Properties

References

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