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Chemical Structure : AZD3839
CAS No.: 1227163-84-9
Catalog No.: PC-43534Not For Human Use, Lab Use Only.
AZD3839 (AZD-3839, AZD 3839) is a potent and selective BACE1 inhibitor with Ki of 26 nM, displays 14- and >1000-fold selectivity against BACE2 and cathepsin D.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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AZD3839 (AZD-3839, AZD 3839) is a potent and selective BACE1 inhibitor with Ki of 26 nM, displays 14- and >1000-fold selectivity against BACE2 and cathepsin D.
AZD3839 inhibits Aβ (Aβ40 IC50=4.8 nM) and sAPPβ release from modified and wild-type human SH-SY5Y cells and mouse N2A cells as well as from mouse and guinea pig primary cortical neurons.
AZD3839 exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate.
AZD3839 demonstrates significant reduction of β-amyloid peptides in mouse brain.
| M.Wt | 431.4125 | |
| Formula | C24H16F3N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Isoindol-3-amine, 1-[2-(difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-, (1S)- |
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1. Swahn BM, et al. J Med Chem. 2012 Nov 8;55(21):9346-61.
2. Jeppsson F, et al. J Biol Chem. 2012 Nov 30;287(49):41245-57.
3. Aasa J, et al. Drug Metab Dispos. 2013 Jan;41(1):159-69.
4. Sparve E, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):469-78.
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