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Chemical Structure : AZD4635
CAS No.: 1321514-06-0
Catalog No.: PC-63144Not For Human Use, Lab Use Only.
AZD4635 (Imaradenant, HTL 1071) is a potent, selective and orally available adenosine 2A receptor (A2AR) inhibitor with Ki of 1.7 nM, > 30-fold selectivity over other adenosine receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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AZD4635 (Imaradenant, HTL 1071) is a potent, selective and orally available adenosine 2A receptor (A2AR) inhibitor with Ki of 1.7 nM, > 30-fold selectivity over other adenosine receptors.
AZD4635 (Imaradenant, HTL 1071) reverses the inhibitory effects of different concentrations of adenosine in CHO cells stably expressing human A2AR with IC50 of 0.1 nM (incubated with 0.1 uM adenosine).
AZD4635 (Imaradenant, HTL 1071) reverses suppression and restores IFNγ secretion in cells incubated with NECA in ex vivo CD8+ T cell assay.
AZD4635 (Imaradenant, HTL 1071) reduces tumor burden and enhances antitumor immunity in vivo.
| M.Wt | 315.736 | |
| Formula | C15H11ClFN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine |
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1. Alexandra Borodovsky, et al. AACR. DOI: 10.1158/1538-7445.
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