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AZD7325

Chemical Structure : AZD7325

CAS No.: 942437-37-8

AZD7325 (AZD-7325, AZD 7325)

Catalog No.: PC-62090Not For Human Use, Lab Use Only.

AZD7325 is a potent, α2/3 functionally selective, partial GABAA receptor positive allosteric modulator with pKi of 9.51.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZD7325 is a potent, α2/3 functionally selective, partial GABAA receptor positive allosteric modulator with pKi of 9.51.
AZD7325 exerts neutral antagonism at the α1-subunit and partial efficacy at the α2,3-subunits over the α5-subunit.
AZD7325 is expected to reduce the risk for the benzodiazepine like side effects, such as sedation and cognitive effects, and shows potential for the treatment of anxiety.

Physicochemical Properties

M.Wt 354.385
Formula C19H19FN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide

References

1. Chen X, et al. Br J Clin Pharmacol. 2014 Dec;78(6):1298-314.

2. Zhou D, et al. Br J Clin Pharmacol. 2012 Jul;74(1):98-108.

3. Jucaite A, et al. Psychopharmacology (Berl). 2017 Feb;234(4):707-716.

4. Alhambra C, et al. Bioorg Med Chem. 2011 May 1;19(9):2927-38.

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