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Chemical Structure : AZD7325
CAS No.: 942437-37-8
Catalog No.: PC-62090Not For Human Use, Lab Use Only.
AZD7325 is a potent, α2/3 functionally selective, partial GABAA receptor positive allosteric modulator with pKi of 9.51.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg (Free Sample) | $28 | In stock | |
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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AZD7325 is a potent, α2/3 functionally selective, partial GABAA receptor positive allosteric modulator with pKi of 9.51.
AZD7325 exerts neutral antagonism at the α1-subunit and partial efficacy at the α2,3-subunits over the α5-subunit.
AZD7325 is expected to reduce the risk for the benzodiazepine like side effects, such as sedation and cognitive effects, and shows potential for the treatment of anxiety.
| M.Wt | 354.385 | |
| Formula | C19H19FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide |
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1. Chen X, et al. Br J Clin Pharmacol. 2014 Dec;78(6):1298-314.
2. Zhou D, et al. Br J Clin Pharmacol. 2012 Jul;74(1):98-108.
3. Jucaite A, et al. Psychopharmacology (Berl). 2017 Feb;234(4):707-716.
4. Alhambra C, et al. Bioorg Med Chem. 2011 May 1;19(9):2927-38.
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