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AZD7687

Chemical Structure : AZD7687

CAS No.: 1166827-44-6

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AZD7687 (AZD 7687, AZD-7687)

Catalog No.: PC-20386Not For Human Use, Lab Use Only.

AZD7687 (AZD-7687) is a potent, selective DGAT1 inhibitor with IC50 of 80 nM (hDGAT1), >400-fold selectivity over hACAT1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AZD7687 (AZD-7687) is a potent, selective DGAT1 inhibitor with IC50 of 80 nM (hDGAT1), >400-fold selectivity over hACAT1.
    AZD7687 potently inhibits human DGAT1 liver microsome with IC50 of 70 nM, and higher inhibitory potency against human adipose tissue with IC50 of 10 nM.
    AZD7687 only shows little to no inhibition of ACAT (79% at 10 μM), FAAH (IC50 = 3.7 μM), muscarinic M2 receptor (IC50 = 80.5 μM), and PDE10A1 in a panel of 339 in vitro radioligand binding and enzyme assays.

    Physicochemical Properties

    M.Wt 367.45
    Formula C21H25N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    {trans-4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl] cyclohexyl}acetic Acid

    References

    1. Barlind JG, et al. J Med Chem. 2012 Dec 13;55(23):10610-29.

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