Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AZD8529 mesylate
Catalog No.: PC-63181Not For Human Use, Lab Use Only.
AZD8529 is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
AZD8529 is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes; potentiates agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus and striatum; decreases nicotine self-administration at doses (0.3-3 mg/kg) in monkeys, also reduces nicotine priming- and cue-induced reinstatement of nicotine seeking, decreases nicotine-induced accumbens dopamine release in rats.
Schizophrenia
Phase 2 Discontinued
| M.Wt | 583.583 | |
| Formula | C25H28F3N5O6S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Justinova Z, et al. Biol Psychiatry. 2015 Oct 1;78(7):452-62.
2. Caprioli D, et al. Biol Psychiatry. 2015 Oct 1;78(7):463-73.
3. Li X, et al. Psychopharmacology (Berl). 2016 May;233(10):1801-14.
4. Augier E, et al. Neuropsychopharmacology. 2016 Nov;41(12):2932-2940.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
