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AZD9898

Chemical Structure : AZD9898

CAS No.: 2042347-69-1

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AZD9898 (AZD-9898)

Catalog No.: PC-73115Not For Human Use, Lab Use Only.

AZD9898 (AZD-9898) is a highly potent, selective and oral inhibitor of leukotriene C4 synthase (LTC4S) with IC50 of 0.28 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZD9898 (AZD-9898) is a highly potent, selective and oral inhibitor of leukotriene C4 synthase (LTC4S) with IC50 of 0.28 nM.
AZD9898 displays nanomolar potency in cells (PBMCs, IC50,free = 6.2 nM).
AZD9898 exhibits good in vivo pharmacodynamics in a calcium ionophore-stimulated rat model after oral dosing (in vivo, IC50,free = 34 nM).

Physicochemical Properties

M.Wt 457.834
Formula C20H19ClF3N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1S,2S)-2-(5-((5-chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino)-3-methoxypyrazine-2-carbonyl)cyclopropane-1-carboxylic acid

References

1. Munck Af Rosenschöld M, et al. J Med Chem. 2019 Sep 12;62(17):7769-7787.

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