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Chemical Structure : Abiraterone acetate
CAS No.: 154229-18-2
Catalog No.: PC-45958Not For Human Use, Lab Use Only.
Abiraterone acetate (CB-7598) is a potent and irreversible CYP17A1 inhibitor with IC50 of 4 nM for 17α-hydroxylase.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $68 | In stock | |
| 100 mg | $98 | In stock | |
| 250 mg | $158 | In stock | |
| 1 g | Get quote |
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Abiraterone acetate (CB-7598) is a potent and irreversible CYP17A1 inhibitor with IC50 of 4 nM for 17α-hydroxylase.
Abiraterone also acts as a partial antagonist of the AR, and as an inhibitor of the 3β-HSD, CYP11B1, and other CYP450s (e.g., CYP1A2, CYP2C9, and CYP3A4).
Abiraterone is highly active in the treatment of castration-resistant prostate cancer; prodrug of the active agent abiraterone and orally acitve.
| M.Wt | 391.5457 | |
| Formula | C26H33NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3b)- |
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1. Jarman M, et al. J Med Chem. 1998 Dec 31;41(27):5375-81.
2. O'Donnell A, et al. Br J Cancer. 2004 Jun 14;90(12):2317-25.
3. Attard G, et al. J Clin Oncol. 2009 Aug 10;27(23):3742-8.
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