Chemical Structure : Ac-FLTD-CMK
CAS No.: 2376255-48-8
Catalog No.: PC-24250Not For Human Use, Lab Use Only.
Ac-FLTD-CMK is a gasdermin D (GSDMD)-derived inhibitor and specific inflammatory caspases inhibitor for caspases-1 (IC50=46.7 nM), caspases-4 (IC50=1.49 μM), caspases-5 (IC50=329 nM), does not inhibit apoptotic caspases such as caspase-3.
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Ac-FLTD-CMK is a gasdermin D (GSDMD)-derived inhibitor and specific inflammatory caspases inhibitor for caspases-1 (IC50=46.7 nM), caspases-4 (IC50=1.49 μM), caspases-5 (IC50=329 nM), does not inhibit apoptotic caspases such as caspase-3.
M.Wt | 569.05 | |
Formula | C26H37ClN4O8 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(4S,7S,10S,13S)-4-Benzyl-13-(2-chloroacetyl)-10-((R)-1-hydroxyethyl)-7-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid |
1. Jie Yang, et al. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797.
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