Ac-IEPD-CHO | Granzyme B inhibitor | Probechem Biochemicals

Chemical Structure : Ac-IEPD-CHO

CAS No.: 352520-90-2

Ac-IEPD-CHO (Ac-Ile-Glu-Pro-Asp-CHO)

Catalog No.: PC-35176Not For Human Use, Lab Use Only.

Ac-IEPD-CHO is a potent, reversible inhibitor of serine protease Granzyme B (GzmB) with Ki of 80 nM, also inhibits caspase-7 (Ki=550 nM) and induces apoptosis.

Packing	Price	Stock
5 mg	$358	In stock
10 mg	$558	In stock
25 mg	$898	In stock
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Biological Activity

Ac-IEPD-CHO is a potent, reversible inhibitor of serine protease Granzyme B (GzmB) with Ki of 80 nM, also inhibits caspase-7 (Ki=550 nM) and induces apoptosis.

Physicochemical Properties

M.Wt	498.533
Formula	C22H34N4O9
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-Acetyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-L-prolinamide

References

1. Shen Y, et al. Exp Mol Med. 2018 May 30;50(5):68.
2. Velthuis JH, et al. Immunobiology. 2003;207(2):115-27.

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Ac-IEPD-CHO (Ac-Ile-Glu-Pro-Asp-CHO)

Biological Activity

Physicochemical Properties

References

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