Chemical Structure : Ac-LESD-CMK
CAS No.:
Ac-LESD-CMK
(N-acetyl-Leu-Glu-Ser-Asp-chloromethylketone)
Catalog No.: PC-24249Not For Human Use, Lab Use Only.
Ac-LESD-CMK is a potent, selective inhibitor of caspase-8 and its homolog caspase-10 with IC50 of 50 nM and 520 nM respectively, Ac-LESD-CMK is a potent and selective inhibitor of caspases-8, -10, and -5.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Ac-LESD-CMK is a potent, selective inhibitor of caspase-8 and its homolog caspase-10 with IC50 of 50 nM and 520 nM respectively, Ac-LESD-CMK is a potent and selective inhibitor of caspases-8, -10, and -5.
Ac-LESD-CMK also is an efficient inhibitor of caspase-5 with IC50 of 2 uM.
Ac-LESD-CMK weakly inhibits the executioner caspases.
Ac-LESD-CMK inhibits the extrinsic apoptotic initiator caspases over 100 fold more potently than Ac-FLTD-CMK。
Ac-LESD-CMK inhibits caspase-1 with IC50 of 3.36 uM.
Ac-LESD-CMK efficiently blocks caspase-5 activity (IC50 = 2 μM) better than Ac-FLTD-CMK (IC50 = 15 μM).
Ac-LESD-CMK weakly inhibits mouse caspase-11 and the executioner caspases-3, -6, and -7.
Ac-LESD-CMK strongly inhibits activation of caspase-8-dependent cell death and modestly inhibits cell death triggered by inflammasome activation.
Physicochemical Properties
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M.Wt
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564.97
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Formula
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C22H33ClN4O11
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(4S,7S,10S,13S)-7-(2-carboxyethyl)-13-(3-chloro-2-oxopropanoyl)-10-(hydroxymethyl)-4-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid
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References
1. Bourne CM, et al. bioRxiv [Preprint]. 2025 Feb 27:2025.02.23.639785.
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