Acrizanib | VEGFR-2 inhibitor | Probechem Biochemicals

Chemical Structure : Acrizanib

CAS No.: 1229453-99-9

Acrizanib (LHA510, LHA-510)

Catalog No.: PC-60029Not For Human Use, Lab Use Only.

Acrizanib (LHA510, LHA-510) is a novel potent, selective VEGFR-2 (KDR) inhibitor with IC50 of 17.4 nM in cell-based assays.

Packing	Price	Stock
1 mg	$98	In stock
5 mg	$238	In stock
10 mg	$398	In stock
25 mg	$598	In stock
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Biological Activity

Acrizanib (LHA510, LHA-510) is a novel potent, selective VEGFR-2 (KDR) inhibitor with IC50 of 17.4 nM in cell-based assays.
Acrizanib (LHA510) exhibits <10% remaining kinase activity against only 13 wildtype kinases, CSF1R, Kit, PDGFRα, PDGFRβ, VEGFR1, VEGFR2, VEGFR3, Fms, DDR1, DDR2, TIE1, and ABL1 in a panel of >400 kinases.
Acrizanib (LHA510) demonstrates potency and efficacy in rodent CNV models, limited systemic exposure after topical ocular administration, multiple formulation options, and an acceptable rabbit ocular PK profile.

Physicochemical Properties

M.Wt	445.406
Formula	C20H18F3N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-({6-[(methylamino)methyl]pyrimidin-4-yl}oxy)-N-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-1H-indole-1-carboxamide

References

1. Adams CM, et al. J Med Chem. 2018 Feb 5. doi: 10.1021/acs.jmedchem.7b01731.

Acrizanib (LHA510, LHA-510)

Biological Activity

Physicochemical Properties

References

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