| Cat. No. |
Product Name |
Information |
| PC-20795 |
Chiauranib
Multikinase inhibitor
|
Chiauranib (Ibcasertib, CS2164) is a potent multi-kinase inhibitor, inhibits VEGFR2, Aurora B and CSF‐1R kinases with IC50 values of 7, 9 and 7 nM, respectively. |
| PC-35892 |
AL3810
VEGFR inhibitor
|
AL3810 (AL-3810, E-3810, Lucitanib) is a potent, orally bioavailable, multiple tyrosine kinases inhibitor, potently inhibits VEGFR1/2/3 (IC50=7-25 nM) and FGFR1/2/3 (IC50=17.5-235 nM), also inhibits CSF1R with IC50 of 5 nM. |
| PC-35129 |
EG01377
NRP1 inhibitor
|
EG01377 is a potent and bioavailable inhibitor of the NRP1/VEGF-A interaction (Kd=1.32 uM), selective for NRP1 over the closely related protein NRP2. |
| PC-63554 |
TAS-115
VEGFR2/c-Met inhibitor
|
TAS-115 (Pamufetinib) is a potent, dual VEGFR2/c-Met inhibitor with IC50 of 30 and 32 nM against rVEGFR2 and rMET, respectively. |
| PC-43483 |
Regorafenib hydrochloride
VEGFR inhibitor
|
Regorafenib hydrochloride (BAY73-4506) is a potent, orally active multikinase inhibitor that potently inhibits endothelial cell kinases in biochemical and cellular kinase phosphorylation assays with nanomolar range (IC50=3-200 nM). |
| PC-63356 |
T-1840383
c-Met/VEGFR-2 inhibitor
|
T-1840383 is a potent, ATP-competitive, dual c-Met/VEGFR-2 inhibitor with IC50 of 1.9, 7.7, 2.2 and 5.5 nM for c-Met, VEGFR1, 2 and 3, respectively. |
| PC-43324 |
Cabozantinib
VEGFR inhibitor
|
Cabozantinib (XL184, BMS-907351) is a potent multi-kinase inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50 of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively. |
| PC-63214 |
AAL993
VEGFR inhibitor
|
AAL993 (ZK260253) is a potent, orally active VEGFR inhibitor with IC50 of 130, 23 and 18 nM for VEGFR-1, 2 and 3, respectively. |
| PC-42960 |
Sulfatinib
VEGFR inhibitor
|
Sulfatinib (HMPL-012) is a potent, multi-targeted tyrosine kinase inhibitor of VEGFR-1/2/3, FGFR1, CSF1R with IC50 of 2/24/1 nM, 15 nM, 4 nM, respectively. |
| PC-61438 |
PAN-90806
|
PAN-90806 (CP-547632, CP547632) is a highly potent, ATP-competitive, orally active VEGFR-2 inhibitor that blocks VEGFR-2 kinase autophosphorylation (IC50=11 nM) and VEGF-induced VEGFR-2 phosphorylation (IC50=5 nM). |
| PC-61437 |
Vorolanib
|
Vorolanib (CM-082) is an orally available, small molecule dual VEGFR/PDGFR kinase inhibitor with antiangiogenic and antineoplastic activities. |
| PC-70185 |
CEP-11981
|
CEP-11981 (ESK981) is a potent, multi-targeted, orally active, pan-VEGFR, TIE-2 and FGFR1 inhibitor with IC50 of 3-100 nM. |
