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EG01377

Chemical Structure : EG01377

CAS No.: 2227996-00-9

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EG01377 (EG-01377;EG 01377)

Catalog No.: PC-35129Not For Human Use, Lab Use Only.

EG01377 is a potent and bioavailable inhibitor of the NRP1/VEGF-A interaction (Kd=1.32 uM), selective for NRP1 over the closely related protein NRP2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    EG01377 is a potent and bioavailable inhibitor of the NRP1/VEGF-A interaction (Kd=1.32 uM), selective for NRP1 over the closely related protein NRP2.
    EG01377 demonstrates antiangiogenic, antimigratory, and antitumor effects in in vitro assays.
    EG01377 blocks glioma-conditioned medium-induced increase in TGFβ production in purified Nrp1+, FoxP3+, and CD25+ populations of Tregs from mice.

    Physicochemical Properties

    M.Wt 586.682
    Formula C26H30N6O6S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3-((5-(4-(Aminomethyl)phenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)-thiophene-2-carbonyl)-L-arginine

    References

    1. Powell J, et al. J Med Chem. 2018 May 10;61(9):4135-4154.

    2. Jarvis A, et al. J Med Chem. 2010 Mar 11;53(5):2215-26.

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