| Cat. No. |
Product Name |
Information |
| PC-42534 |
Brivanib
VEGFR2/FGFR1 inhibitor
|
Brivanib (BMS540215) is a potent, dual inhibitor of VEGFR2 and FGFR1 with IC50 of 25 nM and 148 nM respectively. |
| PC-42622 |
SU14813
Multikinase inhibitor
|
SU14813 is a potent, broad-spectrum RTKs inhibitor with IC50 ranging from 2 to 50 nM for VEGFR-1, VEGFR-2, PDGFRs, KIT, FLT3, and CSF1R/FMS. |
| PC-21859 |
Axitinib
VEGFR inhibitor
|
Axitinib (AG-013736) is a potent, multi-targeted tyrosine kinase inhibitor with IC50 of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively. |
| PC-21447 |
NRPa-308
NRP1 inhibitor
|
NRPa-308 is a neuropilin-1 (NRP-1) antagonist, inhibits the VEGF-A165/NRP-1 binding with IC50 of 42 uM, exerts in vitro anti-angiogenic activity. |
| PC-21310 |
NRP1-4
VEGF-A/NRP1 inhibitor
|
NRP1-4 (Neuropilin 1-4) is a highly potent, specific small molecule inhibitor of VEGF-A binding to neuropilin 1 (NRP1) with IC50 of 0.598 nM, reduces calcium and sodium currents through binding to NRP1 and inhibits the effects of VEGF-A. |
| PC-20705 |
COB223
Angiogenesis inhibitor
|
COB223 is a chemical inhibitor of angiogenesis and tumorigenesis, targets the VEGF signaling pathway upstream of Ras, inhibits endothelial cell migration with IC50 of 5 uM. |
| PC-20338 |
EVT801
VEGFR-3 inhibitor
|
EVT801 (EVT 801) is a potent, selective VEGFR-3 inhibitor with biochemical IC50 of 11 nM, inhibits cellular VEGFR-3 autophosphorylation with IC50 of 39 nM. |
| PC-38754 |
VEGFR inhibitor F16
Angiogenesis inhibitor
|
F16 is a novel specific angiogenesis inhibitor, effectively reduces cell proliferation, tube formation, and migration of HUVECs in a concentration-dependent manner by directly inhibiting VEGF binding and subsequent VEGFR-2 phosphorylation. |
| PC-38423 |
Timtraxanib
VEGFR-2 inhibitor
|
Timtraxanib (AVI 3207) is a peptide mimetic acting as a selective VEGFR-2 inhibitor, inhibits VEGF-2 selectively for curing senile macular degeneration. |
| PC-73181 |
SAR131675
VEGFR3 inhibitor
|
SAR131675 is a potent and selective VEGFR3 inhibitor with IC50 of 23 nM. |
| PC-42859 |
Cabozantinib (S-malate)
|
Cabozantinib (XL184) is a potent, multi-kinase inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50 of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively. |
| PC-42813 |
Nintedanib esylate
|
Nintedanib esylate (BIBF1120 esylate) is a potent triple angiokinase (VEGFR/PDGFR/FGFR) inhibitor with IC50 of 5/38/18/104/5 nM for VEGFR-2/FGFR-1/PDGFRα/VEGFR-1/VEGFR-3, respectively. |
