Catalog No.: PC-42472Not For Human Use, Lab Use Only.
Motesanib diphosphate (AMG706) is a potent, orally bioavailable, multikinase inhibitor inhibitor of VEGFR1/2/3, PDGFR and c-Kit with IC50 of 2-6 nM, 84 nM and 8 nM, respectively.
Motesanib diphosphate (AMG706) is a potent, orally bioavailable, multikinase inhibitor inhibitor of VEGFR1/2/3, PDGFR and c-Kit with IC50 of 2-6 nM, 84 nM and 8 nM, respectively.
Motesanib also displays activity against Ret (IC50=59 nM), no activities against EGFR, Src, and p38.
Motesanib inhibits human endothelial cell proliferation induced by VEGF, but not by bFGF in vitro; potently inhibits VEGF-induced angiogenesis in the rat models.
