Vandetanib hydrochloride is a potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM.
Vandetanib shows weak inhibition for VEGFR3 and EGFR (IC50 is 100 nM and 500 nM respectively).
Vandetanib displays excellent selectivity over erbB2, MEK, CDK-2, Tie-2, IGFR-1R, PDK, PDGFRβ, and Akt (IC50=1.1-100 uM).
Vandetanib has excellent solubility and good oral bioavailability.
