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Nintedanib

Chemical Structure : Nintedanib

CAS No.: 656247-17-5

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Nintedanib (BIBF-1120;BIBF1120)

Catalog No.: PC-45898Not For Human Use, Lab Use Only.

Nintedanib (BIBF-1120) is a potent triple angiokinase (VEGFR/PDGFR/FGFR) inhibitor with IC50 of 5/38/18/104/5 nM for VEGFR-2/FGFR-1/PDGFRα/VEGFR-1/VEGFR-3, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Nintedanib (BIBF-1120) is a potent triple angiokinase (VEGFR/PDGFR/FGFR) inhibitor with IC50 of 5/38/18/104/5 nM for VEGFR-2/FGFR-1/PDGFRα/VEGFR-1/VEGFR-3, respectively.
Nintedanib (BIBF-1120) inhibits MAPK and Akt signaling pathways, show inhibition of cell proliferation (EC50=10-80 nM).
Nintedanib (BIBF-1120) is fully efficacious in xenograft models and orally active.

Physicochemical Properties

M.Wt 539.6248
Formula C31H33N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

References

1. Roth GJ, et al. J Med Chem. 2009 Jul 23;52(14):4466-80.

2. Hilberg F, et al. Cancer Res. 2008 Jun 15;68(12):4774-82.

3. Kudo K, et al. Clin Cancer Res. 2011 Mar 15;17(6):1373-81.

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