| Cat. No. |
Product Name |
Information |
| PC-21310 |
NRP1-4
VEGF-A/NRP1 inhibitor
|
NRP1-4 (Neuropilin 1-4) is a highly potent, specific small molecule inhibitor of VEGF-A binding to neuropilin 1 (NRP1) with IC50 of 0.598 nM, reduces calcium and sodium currents through binding to NRP1 and inhibits the effects of VEGF-A. |
| PC-20705 |
COB223
Angiogenesis inhibitor
|
COB223 is a chemical inhibitor of angiogenesis and tumorigenesis, targets the VEGF signaling pathway upstream of Ras, inhibits endothelial cell migration with IC50 of 5 uM. |
| PC-73181 |
SAR131675
VEGFR3 inhibitor
|
SAR131675 is a potent and selective VEGFR3 inhibitor with IC50 of 23 nM. |
| PC-42859 |
Cabozantinib (S-malate)
|
Cabozantinib (XL184) is a potent, multi-kinase inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50 of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively. |
| PC-42531 |
Regorafenib monohydrate
|
A potent multikinase inhibitor that potently inhibits these endothelial cell kinases in biochemical and cellular kinase phosphorylation assays with nanomolar range (IC50=3-200 nM). |
| PC-42497 |
Vandetanib trifluoroacetate
|
A potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM. |
| PC-43353 |
Cediranib maleate
|
A highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively. |
