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MAZ51

Chemical Structure : MAZ51

CAS No.: 163655-37-6

MAZ51

Catalog No.: PC-23424Not For Human Use, Lab Use Only.

MAZ51 is a specific inhibitor of VEGFR-3, blocks the ligand-induced autophosphorylation of VEGFR-3 and inhibits the proliferation of VEGFR-3-expressing cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MAZ51 is a specific inhibitor of VEGFR-3, blocks the ligand-induced autophosphorylation of VEGFR-3 and inhibits the proliferation of VEGFR-3-expressing cancer cells.
MAZ51 also inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines.
MAZ51 blocks the activity of tyrosine kinases in addition to VEGFR-3.
MAZ51 significantly inhibits the growth of rat mammary carcinomas.

Physicochemical Properties

M.Wt 314.38
Formula C21H18N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one

References

1. Kirkin V, et al. Int J Cancer. 2004 Dec 20;112(6):986-93.

2. Ny A, et al. Blood. 2008 Sep 1;112(5):1740-9.

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