| Cat. No. |
Product Name |
Information |
| PC-63212 |
XL-999
Multikinase inhibitor
|
XL-999 is a potent, multi-targeted receptor tyrosine kinases (RTKs) inhibitor with IC50 of 2.6, 8.2, 1.5 and 0.8 nM for VEGFR-2, FGFR-1, PDGFRβ and FLT-3, respectively. |
| PC-42960 |
Sulfatinib
VEGFR inhibitor
|
Sulfatinib (HMPL-012) is a potent, multi-targeted tyrosine kinase inhibitor of VEGFR-1/2/3, FGFR1, CSF1R with IC50 of 2/24/1 nM, 15 nM, 4 nM, respectively. |
| PC-42875 |
KRN-633
VEGFR-2 inhibitor
|
KRN-633 is a potent, selective VEGFR-2 inhibitor that inhibist the phosphorylation of VEGFR-2 with IC50 of 1.16 nM, also inhibits VEGFR-1, c-Kit and PDGFR-β with IC50 of 11.7, 8.01 and 130 nM. |
| PC-42853 |
Ki8751
VEGFR-2 inhibitor
|
Ki8751 is a potent, selective and orally active VEGFR-2 inhibitor that inhibits VEGFR-2 phosphorylation with IC50 of 0.6 nM. |
| PC-61860 |
SU4312
VEGFR2/PDGFR inhibitor
|
SU 4312 (NSC 86429) is a selective, cell-permeable, brain-penetrant inhibitor of VEGFR2 and PDGFR tyrosine kinase with IC50 of 0.8 and 19.4 uM, respectively. |
| PC-61829 |
AAD777
VEGFR-2 inhibitor
|
AAD777 (NVP-AAD777, ZK202664) is a potent, selective VEGFR-2 kinase inhibitor with IC50 of 0.65 uM, weakly inhibits VEGFR-1 and 3 with IC50 of 2.2 and 3 uM. |
| PC-61438 |
PAN-90806
VEGFR-2 inhibitor
|
PAN-90806 (CP-547632, CP547632) is a highly potent, ATP-competitive, orally active VEGFR-2 inhibitor that blocks VEGFR-2 kinase autophosphorylation (IC50=11 nM) and VEGF-induced VEGFR-2 phosphorylation (IC50=5 nM). |
| PC-61437 |
Vorolanib
VEGFR/PDGFR inhibitor
|
Vorolanib (CM-082) is an orally available, small molecule dual VEGFR/PDGFR kinase inhibitor with antiangiogenic and antineoplastic activities. |
| PC-70185 |
CEP-11981
VEGFR/TIE-2/FGFR1 inhibitor
|
CEP-11981 (ESK981) is a potent, multi-targeted, orally active, pan-VEGFR, TIE-2 and FGFR1 inhibitor with IC50 of 3-100 nM. |
| PC-60029 |
Acrizanib
|
Acrizanib (LHA510, LHA-510) is a novel potent, selective VEGFR-2 (KDR) inhibitor with IC50 of 17.4 nM in cell-based assays. |
| PC-42701 |
EG00229
VEGF-A/NRP1 inhibitor
|
EG00229 is the first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1), selectively inhibits radiolabeled 125I-VEGF-A binding to PAE/NRP1 with IC50 of 8 uM. |
| PC-42637 |
Telatinib
VEGFR inhibitor
|
Telatinib (Bay 57-9352) is an orally active, small molecule inhibitor of VEGFR-2 (IC50=6 nM), VEGFR-3 (IC50=4 nM), PDEGFRα (IC50=15 nM) and c-Kit (IC50=1 nM) in biochemical assays. |
