| Cat. No. |
Product Name |
Information |
| PC-63493 |
CEP-7055
VEGFR inhibitor
|
CEP-7055 is a potent, orally active, pan inhibitor of VEGFR, CEP-7055 is the dimethylglycine ester prodrug of CEP-5214, which inhibits human VEGFR2/KDR kinase, VEGFR1/FLT-1 kinase, and VEGFR3/FLT-4 kinase with IC50 of 18 nM, 12 nM, and 17 nM. |
| PC-63356 |
T-1840383
c-Met/VEGFR-2 inhibitor
|
T-1840383 is a potent, ATP-competitive, dual c-Met/VEGFR-2 inhibitor with IC50 of 1.9, 7.7, 2.2 and 5.5 nM for c-Met, VEGFR1, 2 and 3, respectively. |
| PC-43324 |
Cabozantinib
VEGFR inhibitor
|
Cabozantinib (XL184, BMS-907351) is a potent multi-kinase inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50 of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively. |
| PC-63214 |
AAL993
VEGFR inhibitor
|
AAL993 (ZK260253) is a potent, orally active VEGFR inhibitor with IC50 of 130, 23 and 18 nM for VEGFR-1, 2 and 3, respectively. |
| PC-63212 |
XL999
Multikinase inhibitor
|
XL999 is a potent, multi-targeted receptor tyrosine kinases (RTKs) inhibitor with IC50 of 2.6, 8.2, 1.5 and 0.8 nM for VEGFR-2, FGFR-1, PDGFRβ and FLT-3, respectively. |
| PC-42960 |
Surufatinib
Multikinase inhibitor
|
Surufatinib (Sulfatinib, HMPL-012) is a potent, multi-targeted tyrosine kinase inhibitor of VEGFR-1/2/3, FGFR1, CSF1R with IC50 of 2/24/1 nM, 15 nM, 4 nM, respectively. |
| PC-42875 |
KRN-633
VEGFR-2 inhibitor
|
KRN-633 is a potent, selective VEGFR-2 inhibitor that inhibist the phosphorylation of VEGFR-2 with IC50 of 1.16 nM, also inhibits VEGFR-1, c-Kit and PDGFR-β with IC50 of 11.7, 8.01 and 130 nM. |
| PC-42853 |
Ki8751
VEGFR-2 inhibitor
|
Ki8751 is a potent, selective and orally active VEGFR-2 inhibitor that inhibits VEGFR-2 phosphorylation with IC50 of 0.6 nM. |
| PC-42813 |
Nintedanib esylate
VEGFR inhibitor
|
Nintedanib esylate (BIBF1120 esylate) is a potent triple angiokinase (VEGFR/PDGFR/FGFR) inhibitor with IC50 of 5/38/18/104/5 nM for VEGFR-2/FGFR-1/PDGFRα/VEGFR-1/VEGFR-3, respectively. |
| PC-61860 |
SU4312
VEGFR2/PDGFR inhibitor
|
SU 4312 (NSC 86429) is a selective, cell-permeable, brain-penetrant inhibitor of VEGFR2 and PDGFR tyrosine kinase with IC50 of 0.8 and 19.4 uM, respectively. |
| PC-61829 |
AAD777
VEGFR-2 inhibitor
|
AAD777 (NVP-AAD777, ZK202664) is a potent, selective VEGFR-2 kinase inhibitor with IC50 of 0.65 uM, weakly inhibits VEGFR-1 and 3 with IC50 of 2.2 and 3 uM. |
| PC-61439 |
YM-359445
VEGFR-2 inhibitor
|
YM-359445 (YM359445) is a highly potent, orally active VEGFR-2 inhibitor with IC50 of 8.5 nM, without activity against PKA, PKCα, PDK-1 and JNK3 (IC50>1 uM). |
