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Chemical Structure : Nintedanib esylate
CAS No.: 656247-18-6
Catalog No.: PC-42813Not For Human Use, Lab Use Only.
Nintedanib esylate (BIBF1120 esylate) is a potent triple angiokinase (VEGFR/PDGFR/FGFR) inhibitor with IC50 of 5/38/18/104/5 nM for VEGFR-2/FGFR-1/PDGFRα/VEGFR-1/VEGFR-3, respectively.
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Nintedanib esylate (BIBF1120 esylate) is a potent triple angiokinase (VEGFR/PDGFR/FGFR) inhibitor with IC50 of 5/38/18/104/5 nM for VEGFR-2/FGFR-1/PDGFRα/VEGFR-1/VEGFR-3, respectively.
Nintedanib inhibits MAPK and Akt signaling pathways, show inhibition of cell proliferation (EC50=10-80 nM).
Nintedanib is fully efficacious in xenograft models and orally active.
| M.Wt | 649.7571 | |
| Formula | C33H39N5O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)-, ethanesulfonate (1:1) |
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1. Roth GJ, et al. J Med Chem. 2009 Jul 23;52(14):4466-80.
2. Hilberg F, et al. Cancer Res. 2008 Jun 15;68(12):4774-82.
3. Kudo K, et al. Clin Cancer Res. 2011 Mar 15;17(6):1373-81.
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