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Chemical Structure : Ki8751
CAS No.: 228559-41-9
Catalog No.: PC-42853Not For Human Use, Lab Use Only.
Ki8751 is a potent, selective and orally active VEGFR-2 inhibitor that inhibits VEGFR-2 phosphorylation with IC50 of 0.6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $298 | In stock | |
| 250 mg | Get quote |
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Ki8751 is a potent, selective and orally active VEGFR-2 inhibitor that inhibits VEGFR-2 phosphorylation with IC50 of 0.6 nM.
Ki8751 also inhibits PDGFR family members such as PDGFRα and c-Kit at 67 nM and 40 nM, does not have any inhibitory activity against other kinases such as EGFR, HGFR, InsulinR (IC50>10 uM).
Ki8751 suppressed the growth of the VEGF-stimulated HUVEC on nanomolar level, shows significant antitumor activity against human tumor xenografts such as glioma, stomach carcinoma), lung carcinoma, colon carcinoma and melanoma in nude mice.
| M.Wt | 469.4126 | |
| Formula | C24H18F3N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥92mg/mL; Water: <1.2mg/mL; Ethanol: <1.2mg/mL |
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| Chemical Name/SMILES |
Urea, N-(2,4-difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]- |
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1. Kubo K, et al. J Med Chem. 2005 Mar 10;48(5):1359-66.
2. Arao T, et al. Anticancer Res. 2011 Sep;31(9):2787-96.
3. Hasan MR, et al. Int J Cancer. 2011 Nov 1;129(9):2115-23.
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