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Chemical Structure : CEP-7055
Catalog No.: PC-63493Not For Human Use, Lab Use Only.
CEP-7055 is a potent, orally active, pan inhibitor of VEGFR, CEP-7055 is the dimethylglycine ester prodrug of CEP-5214, which inhibits human VEGFR2/KDR kinase, VEGFR1/FLT-1 kinase, and VEGFR3/FLT-4 kinase with IC50 of 18 nM, 12 nM, and 17 nM.
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CEP-7055 is a potent, orally active, pan inhibitor of VEGFR, CEP-7055 is the dimethylglycine ester prodrug of CEP-5214, which inhibits human VEGFR2/KDR kinase, VEGFR1/FLT-1 kinase, and VEGFR3/FLT-4 kinase with IC50 of 18 nM, 12 nM, and 17 nM.
CEP-7055 demonstrates significant in vivo antitumor activity in numerous tumor models.
| M.Wt | 525.64 | |
| Formula | C32H35N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ruggeri B, et al. Cancer Res. 2003 Sep 15;63(18):5978-91.
2. Gingrich DE, et al. J Med Chem. 2003 Dec 4;46(25):5375-88.
3. Jones-Bolin S, et al. Mol Cancer Ther. 2006 Jul;5(7):1744-53.
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