Catalog No.: PC-61439Not For Human Use, Lab Use Only.
YM-359445 (YM359445) is a highly potent, orally active VEGFR-2 inhibitor with IC50 of 8.5 nM, without activity against PKA, PKCα, PDK-1 and JNK3 (IC50>1 uM).
YM-359445 (YM359445) is a highly potent, orally active VEGFR-2 inhibitor with IC50 of 8.5 nM, without activity against PKA, PKCα, PDK-1 and JNK3 (IC50>1 uM).
YM-359445 inhibits VEGFR2 tyrosine kinase activity completely at 0.03 uM, inhibits HUVEC proliferation induced by VEGF with IC50 of 1.5 nM.
YM-359445 inhibits VEGF-stimulated autophosphorylation of VEGFR2 at 0.1 nM, also inhibits sprout formation of endothelial cells at 3 nM.
YM-359445 not only inhibits tumor growth but also reduces its vasculature in mice bearing various tumors, including paclitaxel-resistant tumors.
