T-1840383 |CAS:1195779-24-8 Probechem Biochemicals

Chemical Structure : T-1840383

T-1840383 (T1840383)

Catalog No.: PC-63356Not For Human Use, Lab Use Only.

T-1840383 is a potent, ATP-competitive, dual c-Met/VEGFR-2 inhibitor with IC50 of 1.9, 7.7, 2.2 and 5.5 nM for c-Met, VEGFR1, 2 and 3, respectively.

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Biological Activity

T-1840383 is a potent, ATP-competitive, dual c-Met/VEGFR-2 inhibitor with IC50 of 1.9, 7.7, 2.2 and 5.5 nM for c-Met, VEGFR1, 2 and 3, respectively.
T-1840383 also potently inhibit several kinases including c-Mer, Ret, Ron, Rse, Tie-2, and TrkA as well as mutants of Abl, c-Kit, FGFR2, and PDGFRα with IC50 of <10 nM.
T-1840383 inhibits HGF-stimulated c-Met phosphorylation (IC50=8.8 nM) in A549 cells, inhibits c-Met–dependent cell proliferation in vitro, inhibits VEGF receptor-2 phosphorylation and VEGF signaling in HUVECs.
T-1840383 shows potent antitumor efficacy in a wide variety of human tumor xenograft mouse models, along with reduction of c-Met phosphorylation levels and microvessel density within tumor xenografts.

Physicochemical Properties

M.Wt	574.009
Formula	C30H25ClFN5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-6-methyl-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide hydrochloride

References

1. Awazu Y, et al. Mol Cancer Ther. 2013 Jun;12(6):913-24.

T-1840383 (T1840383)

Biological Activity

Physicochemical Properties

References

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