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Chemical Structure : T-1840383
Catalog No.: PC-63356Not For Human Use, Lab Use Only.
T-1840383 is a potent, ATP-competitive, dual c-Met/VEGFR-2 inhibitor with IC50 of 1.9, 7.7, 2.2 and 5.5 nM for c-Met, VEGFR1, 2 and 3, respectively.
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T-1840383 is a potent, ATP-competitive, dual c-Met/VEGFR-2 inhibitor with IC50 of 1.9, 7.7, 2.2 and 5.5 nM for c-Met, VEGFR1, 2 and 3, respectively.
T-1840383 also potently inhibit several kinases including c-Mer, Ret, Ron, Rse, Tie-2, and TrkA as well as mutants of Abl, c-Kit, FGFR2, and PDGFRα with IC50 of <10 nM.
T-1840383 inhibits HGF-stimulated c-Met phosphorylation (IC50=8.8 nM) in A549 cells, inhibits c-Met–dependent cell proliferation in vitro, inhibits VEGF receptor-2 phosphorylation and VEGF signaling in HUVECs.
T-1840383 shows potent antitumor efficacy in a wide variety of human tumor xenograft mouse models, along with reduction of c-Met phosphorylation levels and microvessel density within tumor xenografts.
| M.Wt | 574.009 | |
| Formula | C30H25ClFN5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Awazu Y, et al. Mol Cancer Ther. 2013 Jun;12(6):913-24.
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