Catalog No.: PC-61860Not For Human Use, Lab Use Only.
SU 4312 (NSC 86429) is a selective, cell-permeable, brain-penetrant inhibitor of VEGFR2 and PDGFR tyrosine kinase with IC50 of 0.8 and 19.4 uM, respectively.
SU 4312 (NSC 86429) is a selective, cell-permeable, brain-penetrant inhibitor of VEGFR2 and PDGFR tyrosine kinase with IC50 of 0.8 and 19.4 uM, respectively.
SU 4312 displays no significant inhibitory activity against EGFR, HER2, and IGF-1R (>100 uM).
SU 4312 exhibits neuroprotection against MPP(+) at least partly via selective and direct inhibition of nNOS.
SU 4312 inhibits VEGF-dependent angiogenesis in a zebrafish assay (IC50=1.8 uM) without affecting normal cells.
