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Chemical Structure : SU4312
CAS No.: 5812-07-7
Catalog No.: PC-61860Not For Human Use, Lab Use Only.
SU 4312 (NSC 86429) is a selective, cell-permeable, brain-penetrant inhibitor of VEGFR2 and PDGFR tyrosine kinase with IC50 of 0.8 and 19.4 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SU 4312 (NSC 86429) is a selective, cell-permeable, brain-penetrant inhibitor of VEGFR2 and PDGFR tyrosine kinase with IC50 of 0.8 and 19.4 uM, respectively.
SU 4312 displays no significant inhibitory activity against EGFR, HER2, and IGF-1R (>100 uM).
SU 4312 exhibits neuroprotection against MPP(+) at least partly via selective and direct inhibition of nNOS.
SU 4312 inhibits VEGF-dependent angiogenesis in a zebrafish assay (IC50=1.8 uM) without affecting normal cells.
| M.Wt | 264.3 | |
| Formula | C17H16N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one |
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1. Sun L, et al. J Med Chem. 1998 Jul 2;41(14):2588-603.
2. Tran TC, et al. Cancer Res. 2007 Dec 1;67(23):11386-92.
3. Cui W, et al. Br J Pharmacol. 2013 Mar;168(5):1201-14.
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