Catalog No.: PC-42875Not For Human Use, Lab Use Only.
KRN-633 is a potent, selective VEGFR-2 inhibitor that inhibist the phosphorylation of VEGFR-2 with IC50 of 1.16 nM, also inhibits VEGFR-1, c-Kit and PDGFR-β with IC50 of 11.7, 8.01 and 130 nM.
KRN-633 is a potent, selective VEGFR-2 inhibitor that inhibist the phosphorylation of VEGFR-2 with IC50 of 1.16 nM, also inhibits VEGFR-1, c-Kit and PDGFR-β with IC50 of 11.7, 8.01 and 130 nM.
KRN-633 does not inhibits the phosphorylation of FGFR-1, EGFR, or c-Met at 10 uM.
KRN-633 blocks the activation of mitogen-activated protein kinases by VEGF, inhibits VEGF-driven proliferation of HUVECs with IC50 of 14.9 nM.
KRN-633 inhibits tumor growth in several in vivo tumor xenograft models with diverse tissue origins, including lung, colon, and prostate, in athymic mice and rats.
