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Chemical Structure : Cabozantinib
CAS No.: 849217-68-1
Catalog No.: PC-43324Not For Human Use, Lab Use Only.
Cabozantinib (XL184, BMS-907351) is a potent multi-kinase inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50 of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Cabozantinib (XL184, BMS-907351) is a potent multi-kinase inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50 of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
Cabozantinib (XL184, BMS-907351) eliminates tumor vasculature, reduces pericytes and empty basement membrane sleeves.
Cabozantinib (XL184, BMS-907351) causes widespread intratumoral hypoxia and tumor cell apoptosis, and slows regrowth of the tumor vasculature.
Cabozantinib (XL184, BMS-907351) also decreases invasiveness of primary tumors and reduces metastasis in pancreatic islet cancer.
Cabozantinib (XL184, BMS-907351) exerts marked anti-MPNST effects in vitro and in vivo.
| M.Wt | 501.5057 | |
| Formula | C28H24FN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
1,1-Cyclopropanedicarboxamide, N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)- |
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1. You WK, et al. Cancer Res. 2011 Jul 15;71(14):4758-68.
2. Durante C, et al. Expert Opin Investig Drugs. 2011 Mar;20(3):407-413.
3. Torres KE, et al. Clin Cancer Res. 2011 Jun 15;17(12):3943-55.
4. Kurzrock R, et al. J Clin Oncol. 2011 Jul 1;29(19):2660-6.
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