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Chemical Structure : XL999
CAS No.: 705946-27-6
Catalog No.: PC-63212Not For Human Use, Lab Use Only.
XL999 is a potent, multi-targeted receptor tyrosine kinases (RTKs) inhibitor with IC50 of 2.6, 8.2, 1.5 and 0.8 nM for VEGFR-2, FGFR-1, PDGFRβ and FLT-3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $58 | In stock | |
| 10 mg | $98 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | $278 | In stock | |
| 100 mg | $458 | In stock | |
| 250 mg | Get quote |
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XL999 is a potent, multi-targeted receptor tyrosine kinases (RTKs) inhibitor with IC50 of 2.6, 8.2, 1.5 and 0.8 nM for VEGFR-2, FGFR-1, PDGFRβ and FLT-3, respectively.
XL999 also potently inhibits Axl, Kit and Flt-4.
XL999 does not block c-Met but does block many other targets of XL880 and XL184, reduces the vascularity of RIP-Tag2 tumors.
| M.Wt | 445.542 | |
| Formula | C26H28FN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-5-((1-ethylpiperidin-4-yl)amino)-3-((3-fluorophenyl)(5-methyl-1H-imidazol-2-yl)methylene)indolin-2-one |
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1. You WK, et al. Cancer Res. 2011 Jul 15;71(14):4758-68.
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