Chemical Structure : Vandetanib trifluoroacetate
CAS No.:
338992-53-3
Vandetanib trifluoroacetate
(ZD6474 trifluoroacetate;ZD-6474 trifluoroacetate;ZD 6474 trifluoroacetate)
Catalog No. : PC-42497Not For Human Use, Lab Use Only.
A potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4249701
Biological Activity
A potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM; shows weak inhibition for VEGFR3 and EGFR (IC50 is 100 nM and 500 nM respectively); displays excellent selectivity over erbB2, MEK, CDK-2, Tie-2, IGFR-1R, PDK, PDGFRβ, and Akt (IC50=1.1-100 uM); has excellent solubility and good oral bioavailability.
Thyroid Cancer
Approved
Physicochemical Properties
M.Wt
589.3773
Formula
C24H25BrF4N4O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-, 2,2,2-trifluoroacetate (1:1)
References
1. Hennequin LF, et al. J Med Chem. 2002 Mar 14;45(6):1300-12.
2. Wedge SR, et al. Cancer Res. 2002 Aug 15;62(16):4645-55.
3. Carlomagno F, et al. Cancer Res. 2002 Dec 15;62(24):7284-90.
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