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Chemical Structure : Vandetanib trifluoroacetate
CAS No.: 338992-53-3
Catalog No.: PC-42497Not For Human Use, Lab Use Only.
A potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $144 | In stock | |
| 200 mg | $224 | In stock |
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A potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM; shows weak inhibition for VEGFR3 and EGFR (IC50 is 100 nM and 500 nM respectively); displays excellent selectivity over erbB2, MEK, CDK-2, Tie-2, IGFR-1R, PDK, PDGFRβ, and Akt (IC50=1.1-100 uM); has excellent solubility and good oral bioavailability.
Thyroid Cancer
Approved
| M.Wt | 589.3773 | |
| Formula | C24H25BrF4N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-, 2,2,2-trifluoroacetate (1:1) |
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1. Hennequin LF, et al. J Med Chem. 2002 Mar 14;45(6):1300-12.
2. Wedge SR, et al. Cancer Res. 2002 Aug 15;62(16):4645-55.
3. Carlomagno F, et al. Cancer Res. 2002 Dec 15;62(24):7284-90.
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