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Chemical Structure : COB223
Catalog No.: PC-20705Not For Human Use, Lab Use Only.
COB223 is a chemical inhibitor of angiogenesis and tumorigenesis, targets the VEGF signaling pathway upstream of Ras, inhibits endothelial cell migration with IC50 of 5 uM.
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COB223 is a chemical inhibitor of angiogenesis and tumorigenesis, targets the VEGF signaling pathway upstream of Ras, inhibits endothelial cell migration with IC50 of 5 uM.
COB223 inhibits endothelial cell migration and proliferation.
COB223 inhibits also Lewis lung carcinoma (LLC/2) cell proliferation whereas it does not affect fibroblast proliferation.
COB223 (4 mg/kg, i.p.) efficiently reduced the tumor growth rate in a mouse LLC/2 tumor model.
COB223 inhibits endothelial cell ERK1/2 phosphorylation induced by VEGF, FGF-2 or serum and that it acts downstream of PKC and upstream of Ras.
| M.Wt | 533.73 | |
| Formula | C27H43N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Agnès Desroches-Castan, et al. Oncotarget. 2015 Mar 10;6(7):5382-411.
2. Marie Arvin-Berod, et al. ACS Omega. 2017 Dec 31;2(12):9221-9230.
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