Chemical Structure : COB223
CAS No.:
1392267-51-4
COB223
(COB 223, COB-223)
Catalog No.: PC-20705Not For Human Use, Lab Use Only.
COB223 is a chemical inhibitor of angiogenesis and tumorigenesis, targets the VEGF signaling pathway upstream of Ras, inhibits endothelial cell migration with IC50 of 5 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
COB223 is a chemical inhibitor of angiogenesis and tumorigenesis, targets the VEGF signaling pathway upstream of Ras, inhibits endothelial cell migration with IC50 of 5 uM.
COB223 inhibits endothelial cell migration and proliferation.
COB223 inhibits also Lewis lung carcinoma (LLC/2) cell proliferation whereas it does not affect fibroblast proliferation.
COB223 (4 mg/kg, i.p.) efficiently reduced the tumor growth rate in a mouse LLC/2 tumor model.
COB223 inhibits endothelial cell ERK1/2 phosphorylation induced by VEGF, FGF-2 or serum and that it acts downstream of PKC and upstream of Ras.
Physicochemical Properties
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M.Wt
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533.73
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Formula
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C27H43N5O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(OC(C)(C)C)NCCCN1CCN(CCCNS(=O)(C2=C3C=CC=C(N(C)C)C3=CC=C2)=O)CC1
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References
1. Agnès Desroches-Castan, et al. Oncotarget. 2015 Mar 10;6(7):5382-411.
2. Marie Arvin-Berod, et al. ACS Omega. 2017 Dec 31;2(12):9221-9230.
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