Axitinib | VEGFR inhibitor | Probechem Biochemicals

Chemical Structure : Axitinib

CAS No.: 319460-85-0

Axitinib (AG-013736, AG013736)

Catalog No.: PC-21859Not For Human Use, Lab Use Only.

Axitinib (AG-013736) is a potent, multi-targeted tyrosine kinase inhibitor with IC50 of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.

Packing	Price	Stock
100 mg	$88	In stock
200 mg	$128	In stock
500 mg	$188	In stock
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Biological Activity

Axitinib (AG-013736) is a potent, multi-targeted tyrosine kinase inhibitor with IC50 of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.

Physicochemical Properties

M.Wt	386.47
Formula	C22H18N4OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide

References

1. Fenton BM, et al. Cancer Res. 2007 Oct 15;67(20):9921-8.

2. Hu-Lowe DD, et al. Clin Cancer Res. 2008 Nov 15;14(22):7272-83.

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Axitinib (AG-013736, AG013736)

Biological Activity

Physicochemical Properties

References

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